Andrea Dovizioso held the lead for much of the race but finished second, with icon Valentino Rossi grabbing third after an exceptional ride.
Maverick Vinales prevailed at the MotoGP Grand Prix of Qatar in the opening race of the championship, as Yamaha claimed first and third on Sunday.
Spies started the season with fifth place at Losail, his best ever on a MotoGP bike, before retiring in the next two races with a mechanical problem at Jerez and a crash at Le Mans. Spies took his first MotoGP podium at Silverstone in Great Britain, taking a third-place finish. Spies took second place from pole at home at Indianapolis. He finished the 2010 MotoGP season in sixth place, securing Rookie of the Year honours.